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Autopista del Saler , Valencia, Spain. Understanding human pre-implantation development has important implications for assisted reproductive technology ART and for human embryonic stem cell hESC -based therapies. Owing to limited resources, the cellular and molecular mechanisms governing this early stage of human development are poorly understood. Nonetheless, recent advances in non-invasive imaging techniques and molecular and genomic technologies have helped to increase our understanding of this fascinating stage of human development.